[Pyr3]-Beta-Amyloid-Protein (3-42)

[Pyr3]-Beta-Amyloid-Protein (3-42) was found to be the predominant amyloid ?-peptide structure deposited in human brain of Alzheimer's disease and Down's syndrome patients. Therefore, [Pyr3]-Beta-Amyloid-Protein (3-42) is suggested to accumulate in the brain and to trigger the formation of insoluble amyloid ?-peptide deposits. Nussbaum et al. studies the Prion-like behaviour and tau-dependent cytotoxicity of the truncated A? sequence.