[Pyr11]-Beta-Amyloid-Protein (11-40)

[Pyr11]-Beta-Amyloid-Protein (11-40), the N-terminally truncated isoform of the amyloid ?-protein (A?) beginning with a pyroglutamate (Pyr) residue at position 11 was used in experiments studying the generality of fibrillogenesis-related helix formation. Comparing the fibrillogenesis kinetics of many of the most important clinically relevant amyloid ?-protein alloforms it could be observed that among these peptides (Pyr¹¹)-amyloid ?-protein (11-40) exhibited the greatest retardation of fibrillization rate.