Endomorphin-2

Endomorphin-2 (YPFF-amide) shows, as endomorphin-1, the highest affinity and specificity for the mu-opiate receptor found so far in the mammalian nervous system. It has potent mu-selective bioactivity, including analgesia. Szegedi et al. showed that endomorphin-2 protects against A? 1-42 in vitro and in vivo.